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Thorat, V. P.
- Fast Dissolving Drug Delivery System of Cilnidipine using Gelucire 50/13
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Authors
Affiliations
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra 411018, IN
2 Government College of Pharmacy, Osmanpura Aurangabad, Maharashtra 431005, IN
3 Government College of Pharmacy, Ratnagiri, Maharashtra 415612, IN
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra 411018, IN
2 Government College of Pharmacy, Osmanpura Aurangabad, Maharashtra 431005, IN
3 Government College of Pharmacy, Ratnagiri, Maharashtra 415612, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2185-2188Abstract
Cilnidipine is poorly water soluble antihypertensive drug (BCS class II). This study was conducted to increase solubility of drug. An attempt was made to formulate fast dissolving tablet of Cilnidipine by solid dispersion using melting method with Gelucire 50/13. The API: carrier was taken as 1:1, 1:2 and 1:3. Effect of several variables such as concentration of superdisintegrant, drug: carrier ratios were studied. Formulations were analyzed using Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD) analysis, Fourier Transform-Infrared spectroscopy (FT-IR) and in-vitro release studies followed by various release kinetics. The % drug release NLT 85% was obtained by melting method of Cilnidipine: Gelucire 50/13 (1:3) within 15 minutes. Accelerated stability study was carried out for period of 3 months, which indicated prepared formulations were stable.Keywords
Fast Dissolving Tablet, Cilnidipine, Gelucire 50/13, Melting Method, Solid Dispersion.
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